E6201 pharmacokinetic/metric parameters in FVB wild-type mice following administration of single oral dose of 40 mg/kg
Data are presented as mean or mean ± S.E.M. (n = 4).
| Plasma | Brain | |
|---|---|---|
| Half-life (h) | 1.37 | 0.98 |
| Cmax (μg/ml) | 2.44 ± 0.41 | 6.04 ± 1.55 |
| Tmax (h) | 0.5 | 0.5 |
| AUC(0–t) (μg*h/ml) | 3.94 ± 0.54 | 9.23 ± 1.95 |
| AUC(0–∞) (μg*h/ml) | 4.22 | 9.31 |
| CL/F (ml/min per kilogram) | 158 | — |
| Vd/F (l/kg) | 18.7 | — |
| Kp (AUC(0–t) ratio) | - | 2.35 |
| Kp,uu (AUC(0–t) ratio) | - | 0.13 |
| F | 0.39 | — |
AUC(0–t), area under the curve from zero to the time of last measured concentration; AUC(0–∞), area under the curve from zero to time infinity; CL/F, apparent clearance; Cmax, observed maximum concentration; F (absolute bioavailability), ratio of the dose corrected AUC(0–t),PO to dose corrected AUC(0–t),iv; Kp (AUC ratio), the ratio of AUC(0–t,brain) to AUC(0–t,plasma) using total drug concentrations; Kp,uu (AUC ratio), the ratio of AUC(0–t,brain) to AUC(0–t,plasma) using free drug concentrations; PO, by mouth; Tmax, time to reach the maximum concentration; Vd/F, apparent volume of distribution.