TABLE 1

Protein expression levels of transporters/receptors and enzymes in SR-101+ and SR-101 regions of mouse liver and liver zonation index values

Each value of the protein expression level represents the mean ± S.D. (n = 3) in three independent analyses. **P < 0.01, significantly different between SR-101+ and SR-101 regions.

AliasProtein Expression Levels (Mean ± S.D.)Ratio of SR-101+/SR-101
SR-101+SR-101
fmol/mm2fmol/mm2
Slc transporter
 Slc3a2 (4F2hc)0.917 ± 0.2190.834 ± 0.0161.10
 Slc10a1 (Ntcp)6.11 ± 1.424.74 ± 1.161.29
 Slc16a1 (Mct1)13.1 ± 3.09.00 ± 3.101.46
 Slc21a1 (Oatp1a1)30.2 ± 2.715.0 ± 4.8**2.01
 Slc21a10 (Oatp1b2)4.30 ± 1.09U.L.Q. < 2.25>1.91
 Slc22a1 (Oct1)2.43 ± 0.370.470 ± 0.120**5.17
 Slc22a7 (Oat2)0.343 ± 0.1460.781 ± 0.113**0.440
 Slc22a18 (Slc22a18)6.49 ± 1.023.57 ± 0.781.82
 Slc29a1 (Ent1)4.69 ± 0.072.76 ± 0.931.70
Abc transporter
 Abcb4 (Abcb4)1.78 ± 0.391.38 ± 0.271.29
 Abcb11 (Bsep)2.48 ± 0.213.51 ± 0.700.710
 Abcc2 (Mrp2)2.17 ± 0.181.68 ± 0.171.29
 Abcc4 (Mrp4)0.227 ± 0.0440.162 ± 0.0111.40
 Abcc6 (Mrp6)3.04 ± 0.752.19 ± 0.891.39
 Abcg2 (Bcrp)4.16 ± 0.862.82 ± 1.051.48
 Abcg5 (Abcg5)0.939 ± 0.3110.748 ± 0.1421.26
Enzyme
 Cyp2c29 (Cyp2c29)156 ± 7449.0 ± 62.03.18
 Cyp2d22 (Cyp2d22)24.6 ± 5.722.3 ± 7.51.10
 Cyp2e1 (Cyp2e1)76.3 ± 25.91.40 ± 0.10**54.5
 Cyp3a11 (Cyp3a11)68.1 ± 13.765.1 ± 15.71.05
 Cyp8b1 (Cyp8b1)2.58 ± 0.521.67 ± 0.941.54
 Cyp51a1 (Cyp51a1)6.62 ± 0.413.48 ± 1.191.90
 Ugt1a1 (Ugt1a1)45.4 ± 10.219.4 ± 5.12.34
 Ugt1a9 (Ugt1a9)69.4 ± 22.352.1 ± 16.71.33
 Ugt2b36 (Ugt2b36)63.2 ± 6.442.4 ± 13.81.49
 Por (NADPH-CPR)37.7 ± 9.816.1 ± 3.12.34
Other
 Fcgrt (FcRn)4.26 ± 0.593.88 ± 0.541.10
 Glul (GS)168 ± 31U.L.Q. < 0.349>481
 Atp1a1-3 (Na,K-ATPase)13.2 ± 0.4016.6 ± 6.40.795
 Actin460 ± 36451 ± 341.02
  • Abc, ATP-binding cassette; Bcrp, breast cancer resistance protein; Bsep, bile salt export pump; CPR, cytochrome P450 reductase; 4F2hc, 4f2 cell-surface antigen heavy chain; FcRn, neonatal Fc receptor; GS, glutamine synthetase; Mct1, monocarboxylate transporter 1; Ntcp, Na+-taurocholate cotransporting polypeptide; Slc, solute carrier; U.L.Q., under the limit of quantification.