Compound | Mean CLint,liver ± S.E. (ml/min per kilogram BW)a | ||
---|---|---|---|
Microsomes | Hepatocytes | Fold Difference | |
A77-01 | 52 ± 2 | 198 ± 2 | 3.8 |
Bafetinib | 33 ± 1 | 87 ± 8 | 2.7 |
Carbazeran | 28 ± 3 | 208 ± 2 | 7.4 |
CL-387785 | 31 ± 7 | 124 ± 31 | 4.0 |
Duvalisib | 25 ± 1 | 10 ± 0.4 | BQL (0.4)b |
Imatinib | 21 ± 0.05 | 9 ± 0.7 | BQL (0.4)b |
INCB28060 | 26 ± 5 | 17 ± 0.1 | BQL (0.6)b |
Lapatinib | 14 ± 4 | 15 ± 1 | BQL (1.1)b |
Lapatinib M1 | 10 ± 3 | 39 ± 0.8 | 3.8 |
LDN-193189 | 16 ± 0.8 | 72 ± 5 | 4.6 |
Midazolam | 127 ± 12 | 49 ± 1.3 | BQL (0.4)b |
ML-347 | 17 ± 0.2 | 54 ± 0.1 | 3.2 |
SB-525344 | 6 ± 0.1 | 46 ± 0.08 | 7.8 |
VX-509 | 47 ± 0.4 | 15 ± 2 | BQL (0.3)b |
Zoniporide | 4 ± 0.6 | 39 ± 0.6 | 9.2 |