TABLE 1

Effect of genetic variations, age, and gender on UGT2B17 protein abundance and activity

						Glucuronide Formation Activity (pmol/min per mg of Microsomal Protein)
	Protein Abundance (pmol/mg of Microsomal Protein)					T-Glucuronide				DHT-Glucuronide
	n	Mean	Median	Range (Min–Max, Fold Difference)	No. of <LOD Samples	n	Mean	Median	Range (Min-Max, Fold Difference)	n	Mean	Median	Range (Min–Max, Fold Difference)
All samples^{^a}	370	0.92	0.06	0.06–9.7, 162	202	325	15.4	6.4	0.3–184, 558	325	41.8	26.2	1.0–233, 233
CN = 0	53	0	0	—	—	46	5.8	3.7	0.6–20.5, 34	46	27.8	21.2	2.6–90.2, 35
CN = 1	172	0.67	0.06	0.06–6.5, 108	107	133	13.8	6.2	0.3–73.6, 223	133	40.8	27.4	1.0–165, 165
CN = 2	198	1.14	0.19	0.06–9.7, 162	95	146	19.9	7.8	0.5–184, 368	146	47	29.5	1.5–233, 155
Diplotypes
Reference CAGA/CAGA	131	0.57	0.06	0.06–7.9, 132	94	91	13.8	5.7	0.5–123, 246	91	38.7	25.3	2.1–181.4, 86.4
Heterozygous TCAA/CAGG	62	1.59	1.04	0.06–6.02, 100	15	35	27.5	21.4	0.5–98.2, 196	35	63.4	58.8	1.5–160, 107
Homozygous TCAG/TCAG	58	1.63	1.03	0.06–9.7, 162	11	31	30.3	23.2	1.9–184, 96.8	31	66	57	8.3–233, 28
Age categories
Neonatal	3	0.06	0.06	0.06–0.06	3	3	1.1	0.94	0.4–2.0, 5	3	4.8	3.8	1.6–9.0, 5.6
Infancy	23	0.11	0.06	0.06–0.86, 14.3	20	19	3.3	1.3	0.4–11.5, 29	19	14.1	6.2	1.0–55.1, 55.1
Early childhood	38	0.13	0.06	0.06–1.19, 21	34	29	6.6	3.7	0.3–33.1, 110	29	24.8	17.0	1.0–101, 101
Middle childhood	44	0.15	0.06	0.06–1.49, 24.8	34	35	6.0	3.7	0.7–38.9, 56	35	25.0	16.9	2.6–116, 44.6
Adolescence	61	0.81	0.06	0.06–6.9, 115	33	54	18.8	7.9	0.5–131.3, 263	54	48.5	32.1	2.1–194, 92
Adulthood	185	1.33	0.46	0.06–9.7, 162	76	127	23.2	12.6	0.8–185.8, 232	127	56.3	47.4	3.0–235, 78.3
Gender (age 12 yr)
Male	149	1.60	0.91	0.06–9.7, 162	60	108	26.9	18.1	0.5–184, 368	108	60.3	47.6	2.1–232, 110

Female	96	0.57	0.06	0.06–5.5, 92	49	73	13.9	9.2	0.79–98, 124	73	43.3	36.2	2.9–160, 55

↵^a The samples with zero copy number were excluded from the analysis in all categories except the second row. Thirty-two samples (of 455) were excluded from these analyses because copy number (CN) variation data were not available on these samples.