Volumea | Blood Flow Ratea | Kp,Tb | |
---|---|---|---|
ml | ml/min | ||
Adipose | 1.73 | 0.72 | 19.59 |
Liver | 1.10 | 1.94 | 1.52 |
Muscle | 7.67 | 0.91 | 0.68 |
Lungs | 0.15 | 8.14 (Cardiac output) | 1.55 |
Kidneys | 0.33 | 1.30 | 1.28 |
Brain | 0.33 | 0.26 | 2.51 |
Heart | 0.10 | 0.28 | 0.88 |
Spleen | 0.07 | 0.09 | 0.96 |
Skin | 3.30 | 0.41 | 1.29 |
Gastrointestinal tract | 0.85 | 1.50 | 0.91 |
Tumorc | 0.50 | 0.14 | 4.23 |
Rest of body | 3.39 | 2.18 | 0.0090 |
Vein | 0.65 | \ | \ |
Artery | 0.33 | \ | \ |
↵a Volume and blood flow rates of normal tissues were cited from the previous report (Chen et al., 2016).
↵b Kp,T of normal tissues were calculated from the values of rat (Kp,T, rat) (Chen et al., 2016) on the basis of the equation Kp,T = Kp,T, rat · fu/fu, rat, where fu and fu, rat mean unbound fraction of DPT in plasma of tumor-bearing mouse and rat, respectively.
↵c Tumor volume came from the actual volume. Blood flow rate of tumor was cited from the previous report (Zhang et al., 2013). Kp,T value of tumor was calculated from the AUC0–∞ ratio between tumor tissue and plasma of 6.25 mg/kg single intravenous dose group.