Comparison of pharmacokinetic parameters of DPT in plasma and tumor of NCI-H460 tumor-bearing mice following a single intravenous dose estimated from observed and predicted concentration-time profiles by the developed PBPK model
| Plasma | Tumor | ||||
|---|---|---|---|---|---|
| 6.25 mg/kg | 25 mg/kg | 6.25 mg/kg | 25 mg/kg | ||
| AUC0–tn (μM·min) | Obs | 108.47 | 449.85 | 428.62 | 1387.99 |
| Pred | 86.11 | 440.68 | 490.05 | 2322.46 | |
| AUC0–∞ (μM·min) | Obs | 114.90 | 453.42 | 485.60 | 1720.75 |
| Pred | 90.30 | 443.84 | 531.81 | 2520.70 | |
| CL (ml/min per kilogram) | Obs | 136.68 | 138.54 | / | / |
| Pred | 173.91 | 141.52 | / | / | |
| Vss (l/kg) | Obs | 3.30 | 3.53 | / | / |
| Pred | 4.06 | 3.33 | / | / | |
| t1/2 (min) | Obs | 51.21 | 43.96 | 156.96 | 204.67 |
| Pred | 41.83 | 43.60 | 126.38 | 126.38 | |
| Cmax (μM) | Obs | / | / | 2.59 | 15.67 |
| Pred | / | / | 2.18 | 10.33 | |
Cmax, maximum concentration; Obs, observed; Pred, predicted; t1/2, terminal half-life; Vss, apparent volume of distribution at steady state.