TABLE 3

Geometric mean (% CV) and ratio of PK parameters after a single oral 5-mg dose of SAM-760 daily either alone or when coadministered with 400 mg ketoconazole daily

Treatment (N = 12)CmaxAUC0-inf
ng/mlng/h per milliliter
SAM-760, 5 mg3.43 (30)154.5 (26)
SAM-760, 5 mg + ketoconazole, 400 mg4.47 (20)213.7 (18)
[SAM-760+Ketoconazole]/[SAM-760]1.301.38