TABLE 4

Relative abundance of drug-metabolizing enzymes abundance in alcoholic or hepatitis C virus (HCV) cirrhotic vs. control livers (%)

Alcoholic vs. ControlHCV vs. Control
<25%UGT1A6 > >UG/T1A4*>CYP3A4 > UGT2B7 > CYP1A2 > AOX1 > CES1UGT1A6 > >UGT2B7 > CYP1A2 > CYP3A4 > UGT1A4*
25%–50%CYP2E1 > FMO3 > EPHX1 > CYP2A6 > EPHX2 > POR>CYPC8 > CYP2C9AOX1 > CYP2A6 > CES1 > FMO3 > CYP2E1 > EPHX1 > CYP2C9 > EPHX2 > UGT2B15 > CYPC8
50%–100%UGT2B15 > CYP2D6POR
No significant differenceCES2CYP2D6, CES2
  • CES, carboxylesterase; POR, cytochrome P450 reductase.

  • * UGT1A4 abundance was significantly lower in the alcoholic cirrhotic livers vs. HCV cirrhotic livers.