TABLE 1

Average, S.D., and coefficient of variant (CV%) of the 30 most optimized drug-dependent parameter sets of CER selected to minimize the WSS from the observed i.v. and p.o. data after the optimization of model parameters by CNM to explain the pharmacokinetic data under i.v. conditions

Parameters	Units	Initial Range	Average	S.D.	CV%
V_central	L/kg	0.075–0.75	0.092	0.039	42.5
k_a	/h	0.06–6	3.249	1.274	39.2
k_transit	/h	0.06–6	0.769	0.535	69.6
1/β		1.1–10	2.358	1.643	69.7
f_b*CL_int,all	L/h/kg	0.0372–3.72	0.638	0.033	5.2
k_bile	/h	0.06–6	4.029	1.082	26.9
1/f_bile		1.1–10	1.411	0.087	6.2