TABLE 2

Cumulative contribution of P450 isozymes, to each of the 1-ABT–sensitive metabolic pathways of SAM-760 in human hepatocytes, determined using eq. 1, 2, 3

Peak Number in Fig. 2HPLC Rt (min)MRM TransitionCYP2C19CYP2D6CYP3A
min
Peak 31.18549 → 2324.3%
Peak 51.46373 → 2320.47%0.83%
Peak 61.53373 → 1740.06%0.90%
Peak 71.66389 → 1604.5%10%
Peak 81.69549 → 2323.3%
Peak 91.70373 → 2320.69%
Peak 101.91369 → 2280.85%1.1%
Peak 111.91389 → 2480.80%0.90%
Peak 132.0373 → 2323.4%
Peak 142.06288 → 147.15.5%
Peak 15H2.04346 → 160.12.4%
SAM-760 fraction metabolized (fm)N/AN/A6.3%0.47%33%
  • N/A, not applicable.