TABLE 3

Protein abundance of drug-metabolizing enzymes (DMEs) in human livers (picomoles per gram tissue)

ControlAlcoholic CirrhoticHCV Cirrhotic
CYP3A4309.0 ± 240.235.6 ± 39.369.9 ± 88.6
CYP2C969.6 ± 38.631.5 ± 21.029.1 ± 15.3
CYP2D628.2 ± 13.620.3 ± 12.618.1 ± 9.2
CYP2E1190.7 ± 67.150.9 ± 39.577.7 ± 49.5
CYP1A272.3 ± 53.512.5 ± 12.316.2 ± 14.5
CYP2A6192.1 ± 171.769.5 ± 69.560.3 ± 55.7
CYP2C84.6 ± 2.81.9 ± 1.32.1 ± 1.1
POR95.0 ± 40.637.5 ± 12.047.9 ± 18.9
UGT1A4218 ± 109.718.1 ± 21.950.4 ± 32.9
UGT1A634.3 ± 42.51.3 ± 0.61.7 ± 1.1
UGT2B7331.6 ± 388.647.4 ± 31.452.1 ± 35.3
UGT2B1579.7 ± 34.740.9 ± 32.036.2 ± 22.5
CES110,724 ± 53482608 ± 17353837 ± 1961
CES21236 ± 4511026 ± 4101246 ± 677
ADH1A13,549 ± 42282794 ± 20467948 ± 5778
ADH1B141,053 ± 30,11032,980 ± 32,51068,535 ± 53,368
ADH1C16,607 ± 44844297 ± 29677304 ± 5177
ALDH1A113,606 ± 21837743 ± 22518716 ± 2290
CYP3A5<LLOQ<LLOQ<LLOQ
UGT2B6<LLOQ<LLOQ<LLOQ
UGT1A1<LLOQ<LLOQ<LLOQ
UGT2B17<LLOQ<LLOQ<LLOQ
  • POR, cytochrome P450 reductase; HCV, hepatitis C virus; LLOQ, lower limit of quantification.