TABLE 2

Optimized top five drug-dependent parameter sets of GEM/GEM-glu selected to minimize the weighted sum of squares (WSS) from the observed clinical data by Cluster Newton Method (CNM)

ParametersUnitsInitial Range1st2nd3rd4th5th
GEMVcentralL/kg0.075–0.750.0770.0750.0770.0890.076
ka/h0.06–61.4632.5741.6111.2754.733
ktransit/h0.06–63.6452.8722.3786.5851.488
fb*CLint,allL/hr/kg0.0105–1.050.1570.1730.1650.1540.199
1/fglu1.1–101.2101.1181.2631.1051.273
GEM-gluVcentralL/kg0.075–0.750.0760.0760.0870.1500.088
ka/h0.06–60.2580.1090.1060.1550.142
Rdif0.0275–0.110.0510.1030.0640.0790.096
1/β1.1–105.7272.1196.31814.0392.779
fb*CLint,allL/hr/kg0.0156–1.560.2450.1590.2930.3140.184
kbile/h0.06–60.2050.2092.2350.0953.807
kdeconj/h0.06–60.8561.1790.0730.1890.824
kf/h0.06–60.9381.4140.9060.0672.466
WSS1.2021.3191.5141.5211.586