The influence of chloride on GSTZ1 inactivation half-lives
Values shown are mean ± S.D., n = 3. Cytosol and mitochondria were obtained from three human liver samples with GSTZ1C/1C haplotype; *P = 0.02, comparing inactivation t1/2 between cytosolic and mitochondrial GSTZ1 (paired t test).
| GSTZ1 | Average Half-Lives | |
|---|---|---|
| Without Cl− | With Cl− (38 mM) | |
| h | h | |
| Cytosolic | 0.54 ± 0.05 | 5.15 ± 0.11 |
| Mitochondrial | 0.63 ± 0.06 | 3.83 ± 0.44* |