Enzyme kinetic parameters (S.E. in parentheses) for AZD9496 in HLM with the different models
| Equation 1 | Equation 3 | |
|---|---|---|
| HLM 0.025 mg/ml | ||
| Km (µM) | 1.3 (1.0) | 0.4 (0.2) |
| Vmax (pmol/min/mg) | 194 (69) | 93 (8.4) |
| Value of n | 1 | 3 (0.8) |
| Ki (µM) | 3.3 (2.2) | 12 (1.4) |
| HLM 0.25 mg/ml | ||
| Km (µM) | 2.5 (3.7) | 0.8 (0.7) |
| Vmax (pmol/min/mg) | 169 (68) | 76 (12) |
| Value of n | 1 | 1.8 (0.4) |
| Ki (µM) | 2.3 (3.2) | 8.1 (4.4) |