TABLE 2

IC₅₀ and Hill coefficient of inhibitors of organic anion transporting polypeptide (Oatp)–mediated uptake of rosuvastatin (RSV) or olmesartan acid (OLM)

These parameters were estimated using the data in Fig. 4 and Supplemental Fig. 3. The data represent the mean ± S.E. estimated by Phoenix.

Oatp	Substrate	Parameter	BSP	Rifamycin SV	Quinine	Rifampin	Ibuprofen	Olmesartan	Digoxin
1a1	RSV	IC₅₀ (µM)	3.00 ± 0.25	3.33 ± 0.28	72.8 ± 6.5	110 ± 7	485 ± 52	612 ± 43	NI
		H	1.12 ± 0.06	1.08 ± 0.09	0.826 ± 0.057	1.63 ± 0.12	1.23 ± 0.19	0.787 ± 0.090	ND
1a4	RSV	IC₅₀ (µM)	6.24 ± 1.07	20.5 ± 2.9	1.89 ± 0.31	1.31 ± 0.23	NI	NI	0.107 ± 0.015
		H	0.687 ± 0.087	0.746 ± 0.074	0.572 ± 0.048	0.704 ± 0.074	ND	ND	0.575 ± 0.048
1b2	RSV	IC₅₀ (µM)	0.397 ± 0.040	0.140 ± 0.007	125 ± 19	1.12 ± 0.68	48.5 ± 5.1	23.1 ± 4.0	NI
		H	0.938 ± 0.078	1.26 ± 0.06	0.836 ± 0.127	0.752 ± 0.032	0.622 ± 0.042	0.930 ± 0.107	ND
1b2	OLM	IC₅₀ (µM)	0.210 ± 0.050	0.088 ± 0.009	150 ± 30	0.583 ± 0.053	61.4 ± 13.0	ND	NI
		H	1.28 ± 0.29	1.44 ± 0.18	0.745 ± 0.178	0.835 ± 0.063	0.656 ± 0.119	ND	ND

H, Hill coefficient; ND, not determined; NI, not inhibited by 100 µM digoxin or 1000 µM.