Organelle compositions of the various in vitro drug metabolism experimental systems
MMHHs, CCHHs, human liver microsomes (HLM) and postmitochondrial supernatant (PMS). The “X” indicates the presence of the organelles in the specified experimental systems. Organelle contents in various in vitro systems have been previously reviewed (Brandon et al., 2003).
| Organelle | Experimental System | |||
|---|---|---|---|---|
| CCHH | MMHH | HLM | PMS | |
| Plasma membranes | X | X | ||
| Cytosol | X | X | X | |
| Mitochondria | X | X | ||
| Lysosomes | X | X | ||
| Endoplasmic reticulum | X | X | X | X |
| Nucleus | X | X | ||