Proteomic abundance of clinically relevant DMEs
| DME | Jejunum | Ileum | Human Intestinal Microsome |
|---|---|---|---|
| pmol/mg of tissue or microsomal protein | |||
| CYP3A4 | 6.26–9.84 | 8.03–12.9 | 8.8–150 |
| CYP3A5 | ND | ND | 4.9–25 |
| CYP2C19 | <0.122–0.15 | <0.122–0.961 | <0.6–3.9 |
| CYP2D6 | <0.14–1.18 | <0.139–1.16 | <0.2–1.4 |
| CYP2J2 | <4.15–5.28 | 2.71–5.55 | <0.2–3.1 |
| CYP2C9 | 0.034 | 0.009 | 2.9–27 |
| CYP4A11 | <0.126–0.246 | <0.122–0.129 | ND |
| CYP51A1 | 0.722–1.33 | 0.7–1.07 | 3.6–7.7 |
| UGT1A1 | <0.109–4.57 | <0.111–5.05 | ND |
| UGT1A6 | 0.574–1.76 | <0.513–1.54 | ND |
| UGT2B7 | <2.11–5.29 | <2.13–5.59 | ND |
| UGT2B17 | 4.91–50.7 | 7.63–33.7 | ND |
Data are from Paine et al. (1997, 2006) and Drozdzik et al. (2017). ND, Not determined.