TABLE 1
Results (error free; assay error E = 0) arising from the Newton-Raphson method for estimating of Tmax from two- or three-compartmental models
| Two-Compartment, Oral (α = 0.8 h−1, β = 0.2 h−1; k21 = 0.5 h−1; FsysDosepo/V1 = 100) | ||
|---|---|---|
| Fast Absorption (ka = 2 h−1) | Slow Absorption (ka = 0.1 h−1) | |
| C2comp |  |  |
| dC2comp/dt |  |  |
| d2C2comp/dt2 |  |  |
| Tmax,2comp,true (h) | 0.972 | 5.77 |
| Cmax,2comp,true (μg/ml) | 64.2 | 16.3 |
| Three-Compartment, Oral (λ1 = 1.0 h−1; λ2 = 0.8 h−1; λ3 = 0.2 h−1; k21 = 0.5 h−1; k31 = 1.5 h−1) | ||
|---|---|---|
| Fast Absorption (ka = 2 h−1) | Slow Absorption (ka = 0.1 h−1) | |
| C3comp |  |  |
| dC3comp/dt |  |  |
| d2C3comp/dt2 |  |  |
| Tmax,3comp,true (h) | 1.28 | 6.25 |
| Cmax,3comp,true (μg/ml) | 82.4 | 24.2 |
| Multicompartment, Oral (τ = 6; parameters same as above; ka = 2 h−1) | ||
|---|---|---|
| Two-Compartment (Fast Absorption) | Three-Compartment (Fast Absorption) | |
| Cmulti |  |  |
| dCmulti/du |  |  |
| d2Cmulti/du2 |  |  |
| Tmax,multi,true (h) | 0.899 | 1.13 |
| Cmax,multi,true (μg/ml) | 84.3 | 114 |
Dosepo, oral dose administered; Fsys, systemic oral bioavailability, product of fraction absorbed (Fabs) and availabilities of intestine, liver and lung from the first-pass effect; k31, first-order transfer rate from compartment 3 to 1 (three-compartment model).