Human P450-transgenic and P450-humanized mouse models
| Model | Human P450 Transgene Structure | Promoter | Mouse Gene Knockout for Humanization | References |
|---|---|---|---|---|
| CYP1A1/1A2-transgenic | Gene (BAC) | Authentic | None | Jiang et al. (2005) |
| CYP1A1/1A2 humanized | Gene (BAC) | Authentic | Cyp1a1_1a2-null | Dragin et al. (2007) |
| CYP1B1-transgenic | cDNA | Tetracycline-regulated promoter | None | Hwang et al. (2001) |
| CYP1B1 humanized | Gene (BAC) | Authentic | Cyp1b1-null | Li et al. (2014a) |
| CYP2A6-transgenic | cDNA | Mouse transthyretin promoter and enhancer | None | Zhang et al. (2005) |
| CYP2A13/2B6/2F1-transgenic | Gene (BAC) | Authentic | None | Wei et al. (2012) |
| CYP2A13/2B6/2F1 humanized | Gene (BAC) | Authentic | Cyp2a5-null | Megaraj et al. (2014) |
| Cyp2f2-null | Cruzan et al. (2013) | |||
| Cyp2abfgs-null | Li et al. (2014b) | |||
| CYP2A13-humanized | Gene (modified BAC) | Authentic | Cyp2abfgs-null | Jia et al. (2014) |
| CYP2C8-transgenic | cDNA | Mouse Tie2 promoter and enhancer | None | Lee et al. (2010) |
| CYP2C9-humanized | cDNA | Mouse albumin promoter | Cyp2c-null | Scheer et al. (2012a) |
| CYP2C18/2C19-transgenic | Gene (BAC) | Authentic | None | Löfgren et al. (2008) |
| CYP2D6-transgenic | Gene (PAC) | Authentic | None | Corchero et al. (2001) |
| CYP2D6-transgenic | Gene (PAC) | Authentic | None | Cheng et al. (2013) |
| CYP2D6.N-humanized | Gene (BAC) | Authentic | Cyp2d-null | Scheer et al. (2012b) |
| CYP2D6.1-humanized | Gene (modified BAC) | Authentic | Cyp2d-null | Scheer et al. (2012b) |
| CYP2D6.2-humanized | Gene (modified BAC) | Authentic | Cyp2d-null | Scheer et al. (2012b) |
| CYP2E1-transgenic | cDNA | Mouse albumin promoter/enhancer | None | Morgan et al. (2002) |
| CYP2E1-humanized | Gene (BAC) | Authentic | Cyp2e1-null | Cheung et al. (2005) |
| CYP2J2-transgenic | cDNA | Mouse Tie2 promoter and enhancer | None | Lee et al. (2010) |
| CYP3A4-transgenic | Gene (BAC) | Authentic | None | Granvil et al. (2003) |
| CYP3A4-transgenic | cDNA | Human ApoE promoter | None | van Herwaarden et al. (2005) |
| CYP3A4-humanized | cDNA | Human ApoE promoter or mouse villin promoter | Cyp3a-null | van Herwaarden et al. (2007) |
| CYP3A7-transgenic | cDNA | Mouse MT-1 promoter | None | Li et al. (1996) |
| CYP3A4/3A7-transgenic | Gene (BAC) | Authentic | None | Cheung et al. (2006) |
| CYP3A4/3A7-transgenic | Gene (BAC) | Authentic (PXR humanized) | None | Ma et al. (2008) |
| CYP3A4/3A7-humanized | Gene (modified BAC) | Authentic (PXR and CAR humanized) | Cyp3a-null (except for Cyp3a13) | Hasegawa et al. (2011a) |
| CYP3A4/3A5*3/3A7/3A43-humanized | Gene (HAC) | Authentic (CYP3A5 not expressed) | Cyp3a-null | Kazuki et al. (2013) |
| CYP3A4/3A5*1/3A7/3A43-humanized | Gene (modified HAC) | Authentic (CYP3A5 expressed) | Cyp3a-null | Abe et al. (2017) |
| CYP4A11-transgenic | Gene (BAC) | Authentic | None | Savas et al. (2009) |
| CYP4B1-transgenic | cDNA | Human ApoE promoter | None | Imaoka et al. (2001) |
| CYP4F2-transgenic | cDNA (expressing His-tag) | Mouse KAP promoter | None | Liu et al. (2009) |
Models that are derived via cross-breeding between two different human CYP-transgenic models are not included. Authentic, original human CYP promoter was contained in the transgene; KAP, kidney androgen-regulated protein; PAC, P1 phage artificial chromosome.