TABLE 2

Summary of EXE metabolite concentrations in plasma and urine from EXE-treated subjects (n = 132 subjects taking EXE)

	Plasma			Urine
	Mean ± S.E.	Range	Percentage of TEM (Mean ± S.E.)^{^a}	Mean ± S.E.	Range	Percentage of TEM (Mean ± S.E.)^{^a}
	nM			nmol/mg creatinine
EXE	14 ± 1.7	0–105	17 ± 0.91	0.21 ± 0.045	0–3.2	1.7 ± 0.20
17β-DHE	2.5 ± 0.19	0.11–14	12 ± 1.2	0.0066 ± 0.0012	0–0.099	0.14 ± 0.025
17β-DHE-Gluc	30 ± 4.6	0.32–358	36 ± 1.8	1.4 ± 0.37	0.0068–45	21 ± 1.6
6-EXE-cys	22 ± 2.9	0.020–226	23 ± 1.3	5.9 ± 0.69	0.0033–50	55 ± 1.6
6-17β-DHE-cys	5.9 ± 0.58	0–31	12 ± 0.76	1.8 ± 0.19	0.0033–10	22 ± 0.79

↵^a TEM = EXE + 17β-DHE + 17β-DHE-Gluc + 6-EXE-cys + 6-DHE-cys. The percentage of TEM was calculated for EXE or each EXE metabolite for every individual subject, with the mean then calculated for each metabolite of all 132 subjects.