Analyte | Plasma Concentration (ng/ml) | Plasma Concentration Ratio | |||||
---|---|---|---|---|---|---|---|
Placebo | Fluconazole | (Fluconazole/Placebo) | |||||
Median | 25%–75% | Median | 25%–75% | P Value | GMR | 90% CI | |
T | 0.0 | (0.0–3.8) | 3.0 | (0.0–305) | 0.11 | 6.6 | (1.1–40) |
T conj. | 0.0 | (0.0–0.0) | 0.0 | (0.0–13) | 0.094 | 3.7 | (1.1–12) |
M1 | 0.0 | (0.0–0.0) | 2.3 | (0.0–77) | 0.047* | 6.1 | (1.7–21) |
M1 conj. | 2.5 | (0.0–7.7) | 0.0 | (0.0–191) | 0.91 | 1.2 | (0.25–5.5) |
M2 | 0.0 | (0.0–47) | 0.0 | (0.0–6.7) | 0.31 | 0.51 | (0.12–2.1) |
M2 conj. | 1.1 | (0.0–5.8) | 0.0 | (0.0–1.3) | 0.15 | 0.41 | (0.15–1.1) |
M5 | 3.9 | (0.0–81) | 0.0 | (0.0–8.9) | 0.078 | 0.25 | (0.069–0.92) |
M5 conj. | 7.5 | (1.6–169) | 0.0 | (0.0–14) | 0.13 | 0.12 | (0.025–0.57) |
CI, confidence interval; conj., conjugate; T, tramadol.
↵* A P value of less than 0.05 is considered statistically significant.