Lesinurad atropisomer plasma pharmacokinetic parameters (geometric mean and 95% confidence interval)
The P values were determined using a paired t test.
| Treatment | N | Lesinurad | Cmax,ss | Cmin,ss | AUCτ |
|---|---|---|---|---|---|
| µg/ml | µg/ml | µg·h/ml | |||
| Multiple doses day 14 | 11 | Lesinurad racemate | 13.9 (10.9–17.8) | 55.5 (45.7–67.4) | |
| Multiple doses day 14 | 11 | Atropisomer 1 | 6.70 (5.15–8.71) | 0.0228 (0.0130–0.0402) | 26.9 (21.6–33.5) |
| Multiple doses day 14 | 11 | Atropisomer 2 | 8.81 (6.94–11.2) | 0.0913 (0.0631–0.132) | 34.7 (28.9–41.8) |
| Multiple doses day 14 | 11 | Atropisomer 1/atropisomer 2 ratio | 0.760 (0.697–0.828) | 0.250 (0.188–0.333) | 0.775 (0.713–0.841) |
| Multiple doses day 14 | 11 | P value | 0.11 | 0.0009 | 0.04 |
AUCτ, area under the concentration-time curve from time zero to the time of dosing interval.