TABLE 1

Mean reversible protein binding of [14C]acalabrutinib (1, 3, or 10 μM) and ACP-5862 (1 or 10 μM) in mouse, rat, dog, and human plasma and human serum albumin and α1-acid glycoprotein in vitro by ultracentrifugation

SpeciesAcalabrutinibACP-5862
BoundUnboundBoundUnbound
%
Mouse75.424.698.61.4
Rat92.08.099.80.2
Dog68.431.694.35.7
Human97.52.598.61.4
HSA93.76.3NDND
AGP41.158.9NDND
  • AGP, acid glycoprotein; HSA, human serum albumin; ND, not determined.