Mean blood cell partitioning of acalabrutinib (1, 3, or 10 μM) and ACP-5862 (1 or 10 μM) incubated in mouse, rat, dog, monkey, and human whole blood in vitro
| Species | Acalabrutinib | ACP-5862 | ||
|---|---|---|---|---|
| Distribution into Blood Cells | Blood-to-Plasma Ratio | Distribution into Blood Cells | Blood-to-Plasma Ratio | |
| % | % | |||
| Mouse | 56.2 | 1.37 | 23.3 | 0.87 |
| Rat | 29.6 | 0.87 | 73.7 | 2.54 |
| Dog | 49.6 | 1.06 | 67.4 | 1.40 |
| Human | 26.4 | 0.79 | 11.6 | 0.66 |