TABLE 4

Summary of the mean total recovery of radioactivity 0–96 hours after an oral dose of [14C]acalabrutinib to male and female rats and dogs and the geometric mean 0–168 hours after an oral dose to male and female human subjects expressed as a percentage of administered dose

Values are presented as means ± S.D. and geometric means (%CV).

Type of SampleAdministered Dose Recovered
RatDogHuman
Male (n = 3)Female (n = 3)Male (n = 3)Female (n = 3)Overall (n = 6)
%
Urine2.7 ± 0.83.6 ± 0.315.2 ± 1.414.6 ± 3.012.0 (15.9)
Feces91.2 ± 6.088.3 ± 3.671.8 ± 0.769.3 ± 7.983.5 (5.1)
Cage rinse0.2 ± 0.030.8 ± 0.42.5 ± 0.91.6 ± 1.9NA
Carcass0.7 ± 0.11.0 ± 0.5NANANA
Total96.8 ± 3.594.3 ± 2.691.1 ± 0.587.5 ± 6.395.7 (4.5)
  • NA, not applicable.