TABLE 5

Population analysis for drug-drug interaction of 5 mg/kg cefadroxil plus 45 mg/kg cephalexin in human subjects when estimated by the intestinal permeability from huPepT1 mice

Observed values were obtained from the literature (Garrigues et al., 1991).

ParameterObservedSegmental PeffJejunal Peff
PredictedCVErrorPredictedCVError
%%%%
Cmax (μg/ml)8.46.827.4−19.37.516.4−10.5
AUC0–t (μg⋅h/ml)36.829.731.4−19.230.621.7−16.8