TABLE 1

Predicted physicochemical properties of cefadroxil

PropertyCefadroxilSource
Molecular formulaC16H17N3O5S
Molecular weight363.39
Predicted log P (neutral)−2.08ADMET Predictor version 8.5
pK1a2.55Shalaeva et al. (2008)
pK2a7.21Shalaeva et al. (2008)
pK3a9.71Shalaeva et al. (2008)
Aqueous solubility2.68 mg/ml (pH 5.13)ADMET Predictor version 8.5
Diffusion coefficient0.72 × 10−5 cm2/sADMET Predictor version 8.5
Mean precipitation time900 sGastroPlus Default
Drug particle density1.2 g/mlGastroPlus Default
Particle size (radius)25.0 μmGastroPlus Default
Dosage form (human)Solution
Dose volume (human)250 ml