Victim Drug and Its Dose | Clopidogrel 300 mg followed by 75 mg QD Ratio (R) to Placebo (90% or 95% CI, or range) | Gemfibrozil 600 mg BID Ratio (R) to Placebo (90% or 95% CI, or Range) | ||||
---|---|---|---|---|---|---|
AUC0–∞R | CmaxR | Reference | AUC0–∞R | CmaxR | Reference | |
Dasabuvir | ||||||
250 mg | 4.7 (90% CI = 3.2–6.7) | 1.6 (90% CI = 1.0–2.6) | Itkonen et al. (2019) | 11.3 (90% CI = 9.1–14) | 2.0 (90% CI = 1.7–2.4) | Menon et al. (2015) |
Desloratadine | ||||||
5 mg | 2.8 (90% CI = 2.3–3.4) | 1.7 (90% CI = 1.3–2.0) | Present study | 4.6 (90% CI = 3.5–6.2) | 1.7 (90% CI = 1.4–2.2) | Present study |
Montelukast | ||||||
10 mg | 2.0 (90% CI = 1.7–2.3) | 1.0 (90% CI = 0.8–1.2) | Itkonen et al. (2018) | 4.4 (95% CI = 3.8–5.0) | 1.5 (95% CI = 1.3–1.8) | Karonen et al. (2010) |
4.3 (95% CI = 2.9–6.3) | 1.5 (95% CI = 0.9–2.3) | Karonen et al.(2012) | ||||
Pioglitazone | ||||||
1 mg | 2.0 (95% CI = 1.6–2.5)a | Not reported | Kim et al. (2016) | |||
15 mg | 2.1 (90% CI = 1.8–2.6) | 1.0 (90% CI = 0.8–1.4) | Itkonen et al. (2016) | 3.2 (Range = 2.3–6.5) | 1.1 (Range = 0.5–2.6) | Jaakkola et al. (2005) |
30 mg | 3.4 (Range = 2.3–6.2) | Not reported | Deng et al.(2005) | |||
Repaglinide | ||||||
0.1 mg | 3.1 (95% CI = 2.1–4.1)b | Not reported | Kim et al. (2016) | |||
0.25 mg | 5.1 (90% CI = 3.9–6.6) | 2.5 (90% CI = 1.8–3.5) | Tornio et al. (2014) | 8.1 (Range = 5.5–15) | 2.4 (Range = 1.7–6.1) | Niemi et al. (2003) |
3.9 (90% CI = 2.9–5.3)c | 2.0 (90% CI = 1.3–3.1)c | Tornio et al. (2014) | 7.0 (Range = 2.9–14) | 2.2 (Range = 1.4–2.9) | Tornio et al. (2008) | |
7.6 (Range = 4.2–12) | 2.7 (Range = 1.5–3.7) | Backman et al. (2009) | ||||
7.0 (90% CI = 6.0–8.1) | 2.0 (90% CI = 1.6–2.5) | Honkalammi et al. (2012) |
AUC0–8h, area under the plasma concentration –time curve from 0 to 8 hours; AUC0–24h, area under the plasma concentration–time curve from 0 to 24 hours; AUC0–∞, area under the plasma concentration–time curve from time 0 to infinity.
↵a AUC0–24 h ratio.
↵b AUC0–8 h ratio.
↵c Effect on day 3 of treatment with clopidogrel 300 mg on day 1 followed by 75 mg QD.