TABLE 1

Brain, CSF, and plasma concentrations of EPAC in rats following intravenous infusion for 4 h (N = 4)

Concentration at 4 h			Brain/Plasma
Plasma	CSF	Brain	Brain/Plasma
µM	µM	µM	%
0.851 ± 0.18	BQL	0.127 ± 0.039	15 ± 6

BQL, below quantifiable limitation of 0.004 µM.