The 16 transporters selected for inclusion into the meta-analysis after exclusion criteria were applied to determine region-specific transporter expression in the ADAM and M-ADAM models
| Protein | Membrane Localization | Functionality | Quantification (Relative/Absolute)a |
|---|---|---|---|
| SLC10A2 (IBAT) | Apical | Uptake | Relative and absolute |
| SLC15A1 (PEPT1) | Apical | Uptake | Relative and absolute |
| SLC16A1 (MCT1) | Apical | Uptake | Relative |
| SLCO2B1 (OATP2B1) | Apical | Uptake | Relative and absolute |
| SLC22A1 (OCT1) | Apical | Uptake | Relative and absolute |
| SLC22A3 (OCT3) | Apical | Uptake | Relative and absolute |
| SLC22A4 (OCTN1) | Apical | Uptake | Relative |
| ABCB1 (P-gp) | Apical | Efflux | Relative and absoluteb |
| ABCC2 (MRP2) | Apical | Efflux | Relative and absoluteb |
| ABCG2 (BCRP) | Apical | Efflux | Relative and absoluteb |
| SLC2A2 (GLUT2) | Basolateralc | Uptake | Relative |
| SLCO4C1 (OATP4C1) | Basolateralc | Uptake | Relative |
| SLC51A/B (OST-α/β) | Basolateralc | Efflux | Relative and absoluted |
| ABCC1 (MRP1) | Basolateralc | Efflux | Relative |
| ABCC3 (MRP3) | Basolateralc | Efflux | Relative and absolute |
| ABCC4 (MRP4) | Basolateralc | Efflux | Relative |
BCRP, breast cancer resistance protein; MCT1, monocarboxylate transporter 1; PEPT1, peptide transporter 1.
↵a Relates to data available and collated in the final database (i.e., without exclusion criteria applied) (see Fig. 1) for a transporter.
↵b A substantial meta-analysis for relative expression of P-gp, MRP2, and BCRP had already been performed, and the results are published in Harwood et al. (2013).
↵c Note that the M-ADAM model requires selection to enable activation of the basolateral membrane localized transporters.
↵d Data collated distinctly for α (SLC51A) and β (SLC51B) subunits, hence counted as individual transporters in the Fig. 1 count of transporter data collated.