The 16 transporters selected for inclusion into the meta-analysis after exclusion criteria were applied to determine region-specific transporter expression in the ADAM and M-ADAM models

ProteinMembrane LocalizationFunctionalityQuantification (Relative/Absolute)a
SLC10A2 (IBAT)ApicalUptakeRelative and absolute
SLC15A1 (PEPT1)ApicalUptakeRelative and absolute
SLC16A1 (MCT1)ApicalUptakeRelative
SLCO2B1 (OATP2B1)ApicalUptakeRelative and absolute
SLC22A1 (OCT1)ApicalUptakeRelative and absolute
SLC22A3 (OCT3)ApicalUptakeRelative and absolute
SLC22A4 (OCTN1)ApicalUptakeRelative
ABCB1 (P-gp)ApicalEffluxRelative and absoluteb
ABCC2 (MRP2)ApicalEffluxRelative and absoluteb
ABCG2 (BCRP)ApicalEffluxRelative and absoluteb
SLC2A2 (GLUT2)BasolateralcUptakeRelative
SLCO4C1 (OATP4C1)BasolateralcUptakeRelative
SLC51A/B (OST-α/β)BasolateralcEffluxRelative and absoluted
ABCC1 (MRP1)BasolateralcEffluxRelative
ABCC3 (MRP3)BasolateralcEffluxRelative and absolute
ABCC4 (MRP4)BasolateralcEffluxRelative
  • BCRP, breast cancer resistance protein; MCT1, monocarboxylate transporter 1; PEPT1, peptide transporter 1.

  • a Relates to data available and collated in the final database (i.e., without exclusion criteria applied) (see Fig. 1) for a transporter.

  • b A substantial meta-analysis for relative expression of P-gp, MRP2, and BCRP had already been performed, and the results are published in Harwood et al. (2013).

  • c Note that the M-ADAM model requires selection to enable activation of the basolateral membrane localized transporters.

  • d Data collated distinctly for α (SLC51A) and β (SLC51B) subunits, hence counted as individual transporters in the Fig. 1 count of transporter data collated.