Kinetic parameters of NC-induced inhibition of E2 hydroxylation activity of CYP1A1, CYP1B1, and CYP1A2
Data represent the mean ± S.D. (n = 3).
| CYP1 Enzyme | E2 Hydroxylation | |||
|---|---|---|---|---|
| E2 Hydroxylation Site | Type of Inhibition | Ki | KI | |
| μM | μM | |||
| 1A1 | 2-OHE2 | Mixed | 0.052 ± 0.007 | 0.210 ± 0.016 |
| 4-OHE2 | Competitive | 0.26 ± 0.03 | ||