TABLE 2

Kinetic parameters of NC-induced inhibition of EROD activity of CYP1A1, CYP1B1, and CYP1A2

Data represent the mean ± S.D. (n = 3).

CYP1 EnzymeEROD
Type of InhibitionKiKI
μMμM
1A1Mixed0.14 ± 0.040.19 ± 0.09
1B1Competitive0.47 ± 0.05