TABLE 2

In vivo comparison of compound 11 and compound 19

Compound 11 (16 mg/kg)Compound 19 (5 mg/kg)
i.p.POi.p.PO
t1/2 (min)19.811.468.6272.8
AUC (min*µg/ml)29424.6838.1155.8
Cmax (µg/ml)10.161.444.10.4
CL (ml/min/kg)54.375.96
F (%)8.418.6
  • PO, by mouth.