Summary of Pearson correlation results for in vivo clearance (Cl), percentage remaining in hepatocyte media, HIC retention time, and FcRn binding at pH 7.4 or 5.5
| x-Axis Data | y-Axis Data | Pearson r | N | P Value | Significant |
|---|---|---|---|---|---|
| HIC RT | In vivo Cl | 0.8005 | 12 | 0.0018 | Yes |
| Percentage remaining in media | In vivo Cl | −0.5525 | 15 | 0.0327 | Yes |
| HIC RT | Percent remaining in media | −0.7185 | 15 | 0.0085 | Yes |
| FcRn (pH 7.4) | In vivo Cl | 0.9107 | 7 | 0.0044 | Yes |
| FcRn (pH 5.5) | In vivo Cl | 0.8088 | 7 | 0.0276 | Yes |
| FcRn (pH 7.4) | HIC RT | 0.7144 | 6 | 0.1129 | No |
| FcRn (pH 5.5) | HIC RT | 0.8449 | 6 | 0.0342 | Yes |
| FcRn (pH 7.4) | Percent remaining in media | −0.9455 | 7 | 0.0013 | Yes |
| FcRn (pH 5.5) | Percent remaining in media | −0.3902 | 7 | 0.3868 | No |
RT, retention time.