TABLE 2

Plasma protein binding in mouse, monkey, and man

Values are an average of three measurements ± S.D.

Nominal Plasma Volanesorsen ConcentrationExtent of Plasma Protein Binding
HumanMonkeyMouse
µg/ml%%%
599.24 ± 0.0799.78 ± 0.0498.12 ± 1.10
15098.01 ± 0.1499.48 ± 0.0897.19 ± 0.47