TABLE 1

List of peptide conjugates

Conjugate	Ab Core	Linker^a	Peptide	Peptide Charge	In Vivo Clearance	AUC_intact/AUC_total	Percentage Remaining in Hep Media	FcRn at pH 7.4	FcRn at pH 5.5	HIC Retention Time
					l/h/kg					min
aDNP	aDNP D88C	N/A	N/A	N/A	0.0006	N/A	93	21.5	0.8	3.90
1	aDNP D88C	PEG11	AM-0422	6	0.0205	0.1	57.7
2	aDNP E384C	bisPEG23	AM-0422	6	0.079	ND	38
3	aDNP D88CC	PEG11	AM-6122	2	0.00175	0.33	74	92.5	25.1
4	aDNP D88C	GGS	AM-2752	2	0.0044	0.42	47.8	147	30.9	5.18
5	aDNP E384C	GGS	AM-2752	2	0.0032	0.76	88	47.7	239.2	5.69
6	aDNP D88C	GGS	AM-5454	1	0.0062	0.51	76			5.43
7	aDNP D88C	GGS	AM-5759	1	0.0024	0.27	74.9			5.45
8	aDNP D88C	GGS	AM-5458	1	0.0045	0.61	74.8			5.42
9	aDNP-3A4-F D88C	GGS	AM-6918	1	0.0037	0.36	72.6			5.61
10	aDNP-3A4-F D88C	GGS	AM-6262	1	0.0083	0.26	39	228.1	337	6.46
11	3B1HC-3A4LC D88C	GGS	AM-2752	2	0.0033	0.44	63.8	79.7	93.7	5.71
12	3B1HC-3A4LC D88C	GGS	AM-2752	2	0.0013	0.4	73.4	73.1	34.6	4.92
13	aDNP-3A4-F D88C	GGS	AM-8960	1	0.0013	0.24	75.6			5.43
14	aDNP-3A4-F D88C	PEG11	AM-8248	1	0.0118	0.28	37.6			6.65

Ab, antibody; bisPEG23, bis-23-unit polyethylene glycol; GGS, glycine-glycine-serine; Hep, %ID/g, percent injected dose per gram; N/A, not applicable; ND, data not collected; PEG11, 11-unit polyethylene glycol.