TABLE 2

8-Hydroxyefavirenz and 8,14-dihydroxyefavirenz formation in low substrate concentration range

S-Efavirenz8-Hydroxyefavirenz8,14-diOH-efavirenzEmbedded ImageEmbedded Image
µMpmol/min per picomolespmol/min per picomoles%%
0.2500.014 ± 0.0100100
0.50.001 ± 0.0010.055 ± 0.046298
1.250.055 ± 0.0090.209 ± 0.0332179
2.50.332 ± 0.0480.460 ± 0.1824258
5.01.46 ± 0.290.405 ± 0.0787822
102.43 ± 0.100.505 ± 0.1448317
204.03 ± 0.280.201 ± 0.095955