TABLE 1

CYP2B6 variants

CYP2B6 AlleleVariantcDNA Sequence MutationProtein Sequence MutationaAllele Frequency (%)
CYP2B6*1Wild-typeWild-type
CYP2B6*4rs2279343785A>GK262R2-4 Ca
CYP2B6*5rs32113711459C>TR487C12 Ca
CYP2B6*6rs3745274, rs2279343516G>T, 785A>GQ172H/K262R33 Af, 28 Ca
CYP2B6*7rs3745274, rs2279343, rs3211371515G>T, 785A>G, 1459C>TQ172H/K262R/R487C3 Ca
CYP2B6*9rs3745274516G>TQ172H
CYP2B6*16rs2279343, rs28399499785A>G, 983T>CK262R/I328T6.9 Af
CYP2B6*17rs33973337, rs33980385, rs3392610476A>T, 83A>G, 85C>A, 86G>CT26S/D28G/R29T6.3 Af
CYP2B6*18rs28399499983T>CI328T9.4 Af
CYP2B6*19rs34826503516G>T, 785A>G, 1006C>TQ172H/K262R/R336C1.6 Af
CYP2B6*26rs3826711, rs2279343, rs3745274499C>G, 516G>T, 785A>GP167A/Q172H/K262R1.3 As
  • Af, African; As, Asian; Ca, Caucasian.

  • a All CYP2B6 variants result in missense mutations.