TABLE 5

Summary of reported 8-hydroxylation of S-efavirenz

Relative activities are shown as percentage of CYP2B6 variants Clint (Clmax for this study) compared with the wild type, on the basis of data in Table 3.

Bumpus et al., 2006Ariyoshi et al., 2011Zhang et al., 2011Xu et al., 2012Radloff et al., 2013Watanabe et al., 2018This Study (Clmax)
Expression systemE. coliSf9E. coliSF9COS-1HEKT. ni
CYP2B6.1100100100100100100100
CYP2B6.417014296122144
CYP2B6.51388310992
CYP2B6.650204918326656
CYP2B6.715616659
CYP2B6.93317248
CYP2B6.178589
CYP2B6.193748
CYP2B6.2618356