Genotype and variant allele frequency distribution among pregnant and nonpregnant women with uncomplicated P. falciparum infection
| Genotype | Pregnant Women Frequency N (%) | Nonpregnant Women Frequency N (%) | P Value |
|---|---|---|---|
| CYP3A4*1B (- 392A>G) | 0.809 | ||
| *1/*1 | 19 (9.4%) | 5 (6.9%) | |
| *1/*1B | 80 (39.6%) | 30 (41.7%) | |
| *1B/*1B | 103 (51.0%) | 37 (51.4%) | |
| CYP3A5*3 c.6986A>G | 0.881 | ||
| *1/*1 | 118 (59.3%) | 43 (62.3%) | |
| *1/*3 | 75 (37.7%) | 24 (34.8%) | |
| *3/*3 | 6 (3.0%) | 2 (2.9%) | |
| CYP3A5*6 c.14690G>A | 0.480 | ||
| *1/*1 | 145 (71.4%) | 51 (71.8%) | |
| *1/*6 | 49 (23.9%) | 19 (26.8%) | |
| *6/*6 | 9 (4.4%) | 1 (1.4%) | |
| CYP3A5*7 | 0.781 | ||
| 27131_27132insT | |||
| *1/*1 | 156 (77.6%) | 53 (73.6%) | |
| *1/*7 | 43 (21.4%) | 18 (25.0%) | |
| *7/*7 | 2 (1.0%) | 1 (1.4%) | |
| ABCB c.3435 | 0.672 | ||
| CC | 139 (72.0%) | 53 (74.6%) | |
| CT | 51 (26.4%) | 16 (22.5%) | |
| TT | 3 (1.6%) | 2 (2.8%) | |
| ABCB rs3842 | 0.269 | ||
| AA | 116 (57.1%) | 39 (54.2%) | |
| AG | 70 (34.5%) | 31 (43.1%) | |
| GG | 17 (8.4%) | 2 (2.8%) | |
| Allele | Minor Allele | Pregnant Women | Nonpregnant Women |
| CYP3A4*1B (- 392A>G) | *1B | 70.8 | 72.2 |
| CYP3A5*3 c.6986A>G | *3 | 21.9 | 20.3 |
| CYP3A5*6 c.14690G>A | *6 | 16.4 | 14.8 |
| CYP3A5*7 27131_27132insT | *7 | 13 | 13.9 |
| ABCB c. 3435 | T | 14.8 | 14.1 |
| ABCB rs3842 | G | 25.7 | 24.4 |