TABLE 3

Factors affecting log day 7 LF plasma concentration

VariablenUnivariate AnalysisMultivariable Analysis
Beta Coefficient (95% CI)P ValueBeta Coefficient (95% CI)P Value
Pregnancy209−14.5 (4.9–24.2)0.003−27.1 (5.0–49.3)0.009
Age (years)2090.3 (−0.2 to 0.9)0.237
Weight (kg)2080.8 (0.3–1.2)0.0021.8 (0.7–2.8)0.002
Hemoglobin (g/dl)2083.2 (0.2–6.2)0.036NS
Trimester14219.1 (2.8–35.5)0.022NS
Gravida1427.2 (−19.6 to 5.2)0.253
Parasitemia (counts/µl)
 <1000404.0 (−7.4 to 15.4)0.484
 1000–10,0001583.9 (−17 to 24.8)0.710
 >10,00011Reference
CYP3A4*1B0.046NS
CYP3A4*1/*121−9.2 (1.4–17)0.022
CYP3A4*1/*1B831.5 (−8.1 to 11.1)0.759
CYP3A4*1B/*1B104Reference
Number of CYP3A5*1 allele0.002
 Zero509.0 (2.5–15.5)0.00715.5 (6.3–24.8)0.002
 One9510.1 (−0.4 to 20.5)0.0596.6 (−18.1 to 31.2)0.591
 Two63ReferenceReference
ABCB rs38420.70NS
 A/A118−2.1 (−13.0 to 8.7)0.695
 A/G80−0.4 (−21.3 to 20.5)0.969
 G/G11Reference
ABCB c. 3435 C>T0.14NS
 C/C143−16.5 (−33.4 to 0.4)0.056
 C/T54−29.8 (−63.1 to 3.4)0.078
 T/T4Reference
  • NS, Nonsignificant variables.