Effects of K3Fe(CN)6 on the inactivation of CYP3A
Data represent the mean ± S.D. (n = 3). The percentage of CYP3A activity was determined by calculation of the ratio of enzyme activity of each sample after 0 or 20 minute incubation with PPR vs. that of the corresponding control sample without PPR treatment. % Reversed stands for the contribution of KFC to the recovered activity of CYP3A.
| System | CYP3A | |
|---|---|---|
| % Control (0 min) | % Control (20 min) | |
| −KFC | 50.7 ± 2.9 | 40.5 ± 2.6 |
| +KFC | 86.3 ± 8.4 | 80.2 ± 15.7 |
| % Reversed | / | 39.7 |
KFC, potassium ferricyanide.