Expression levels of enzymes (P450 and UGT) with known involvement in drug metabolism in human intestine
Protein expression is represented by the mean, the S.D. of the mean, the %CV, and the range (min-max). Protein abundance is reported in picomoles per milligram of total mucosal protein.
| Jejunum (n = 4) | Ileum (n = 12) | |
|---|---|---|
| Mean ± S.D. (%CV) and Range (min-max) | Mean ± S.D. (%CV) and Range (min-max) | |
| CYP2C9 | 1.52 ± 0.61 (40.32) | 1.42 ± 0.60 (42.11) |
| (0.81–2.17) | (0.92–3.04) | |
| CYP2C19 | 1.08 ± 0.11 (10.16) | 1.25 ± 0.60 (47.78) |
| (0.99–1.23) | (0.79–3.04) | |
| CYP2D6 | 1.91 ± 0.46 (23.90) | 1.64 ± 0.55 (33.54) |
| (1.31–2.30) | (1.00–2.63) | |
| CYP2J2 | 1.04 ± 0.30 (28.52) | 0.90 ± 0.16 (17.90) |
| (0.72–1.43) | (0.62–1.11) | |
| CYP3A4 | 33.33 ± 5.70 (17.11) | 22.04 ± 10.60 (48.10) |
| (24.80–36.75) | (7.58–34.70) | |
| UGT1A1 | 2.93 ± 2.17 (73.83) | 1.52 ± 0.55 (36.50) |
| (0.83–5.35) | (0.72–2.58) | |
| UGT1A3 | 1.26 ± 0.29 (22.64) | 1.10 ± 0.23 (20.50) |
| (0.87–1.54) | (0.90–1.69) | |
| UGT1A6 | 0.75 ± 0.02 (2.12) | 0.75 ± 0.02 (3.25) |
| (0.74–0.77) | (0.71–0.79) | |
| UGT2B7 | 1.84 ± 0.97 (53.07) | 1.17 ± 0.23 (19.34) |
| (1.03–3.03) | (0.88–1.65) | |
| UGT2B15 | 0.39 ± 0.03 (8.37) | 0.37 ± 0.03 (9.26) |
| (0.34–0.41) | (0.32–0.44) |