Accuracy (GMFE and classification success) and bias of human fg predictions based on in vitro assays in three intestinal models
| Intestinal Microsomes | Permeabilized Enterocytes | Intestinal Mucosa | |
|---|---|---|---|
| GMFE | |||
| Overall | 2.62 | 2.81 | 2.81 |
| Low (fg 0–0.3) | 4.21 | 3.26 | 3.85 |
| Moderate (fg 0.31–0.70) | 4.12 | 5.06 | 5.76 |
| High (fg 0.71–1.0) | 1.23 | 1.53 | 1.21 |
| Classification success | |||
| Overall | 58.6% | 51.7% | 62.1% |
| Low (fg 0–0.3) | 66.7% | 66.7% | 66.7% |
| Moderate (fg 0.31–0.70) | 22.2% | 33.3% | 22.2% |
| High (fg 0.71–1.0) | 81.8% | 45.5% | 90.9% |
| Overprediction bias | |||
| Overall | 50.0% | 28.6% | 50.0% |
| Low (fg 0–0.3) | 55.6% | 33.3% | 33.3% |
| Moderate (fg 0.31–0.70) | 62.5% | 37.5% | 37.5% |
| High (fg 0.71–1.0) | 36.4% | 18.2% | 72.7% |
| Underprediction bias | |||
| Overall | 50.0% | 71.4% | 50.0% |
| Low (fg 0–0.3) | 44.4% | 66.7% | 66.7% |
| Moderate (fg 0.31–0.70) | 37.5% | 62.5% | 62.5% |
| High (fg 0.71–1.0) | 63.6% | 81.8% | 27.3% |