Macro- and microcompartmental PK parameter estimates and metrics of AML, DIG, and GLY calculated with a two-compartmental model for naïve-pooled average rat (n = 3) upon an intravenous bolus dose
The naïve-pool average estimates are listed as estimate ± standard error.
| Parameter | AML (2 mg/kg) | DIG (0.25 mg/kg) | GLY (4 mg/kg) |
|---|---|---|---|
| A (ng/mL) | 271 ± 17.5 | 155 ± 5.37 | 13201 ± 367 |
| α (h-1) | 5.55 ± 0.5 | 3.06 ± 0.21 | 3.75 ± 0.18 |
| B (ng/mL) | 86 ± 3.84 | 32.2 ± 3.63 | 2698 ± 162 |
| β (h-1) | 0.24 ± 0.01 | 0.42 ± 0.03 | 0.390 ± 0.016 |
| k12 (h-1) | 2.57 ± 0.13 | 1.10 ± 0.12 | 1.65 ± 0.1 |
| k21 (h-1) | 1.26 ± 0.05 | 0.830 ± 0.035 | 0.96 ± 0.06 |
| k10 (h-1) | 0.808 ± 0.03 | 1.45 ± 0.08 | 1.52 ± 0.04 |
| Vc (mL) | 1767 ± 45.5 | 441 ± 14.9 | 73.9 ± 1.76 |
| CL (mL/h) | 1442 ± 80 | 1924 ± 167 | 112.4 ± 6.0 |
| VDss (mL) | 5321 ± 590 | 3032 ± 527 | 201.2 ± 21 |
| t1/2 (h) | 2.89 ± 0.23 | 1.66 ± 0.20 | 1.78 ± 0.13 |
| AUC(0 - ∞) (ng•h/mL) | 407.2 ± 23 | 127.7 ± 11 | 10448 ± 539 |