TABLE 3

Observed and predicted C_max, tmax, and EOC for AML, DIG, and GLY. Observed metrics are listed based on the naïve-pooled datasets.

Drug	Group	AUC_0-inf obs (ng.h/ml)	C_max obs (ng/ml)	C_max pred (ng/ml)	tmax obs (h)	tmax pred (h)	EOC
AML	Fasted 2 h FT	274	34.8	39.4	2.5	2.5	0.92
	Fasted 1 h FT	435	36.6	51.3	4.0	1.2	0.89
	Fed	475	18.6	18.2	21.8	19.6	0.97
DIG	Fasted 1 h FT	77	11.1	11.1	0.7	1.5	0.88
	Fasted 0.5 h FT	80	10.1	7.84	0.2	1.3	0.80
	Fed	193	13.5	8.0	0.2	1.9	0.84
GLY	Fasted 2 h FT	5.1	2.18	1.20	1.5	2.3	0.82
	Fasted 1 h FT	4.8	0.50	0.5	0.5	1.4	0.93
	Fed	3.6	0.19	0.15	2.5	9.7	0.94