AUC0– 24 values of CLB and NCLB and AUC ratios (NCLB/CLB) in hCYP3A/3aKO and hCYP3A/2c3aKO mice Data are shown as means ± S.D. (n = 4 per group). Data for hCYP3A/2c3aKO mice treated with phenobarbital are individual values of two mice because two mice died. *P < 0.05 compared with hCYP3A/3aKO mice (Welch’s t test); ***P < 0.001 compared with hCYP3A/3aKO mice (Student’s t test); #P < 0.05, ##P < 0.001 compared with control (paired samples t test).
| Compounds | CLB Alone | Phenobarbital + CLB | |||
|---|---|---|---|---|---|
| hCYP3A/3aKO | hCYP3A/2c3aKO | hCYP3A/3aKO | hCYP3A/2c3aKO | ||
| CLB (µg·hr/mL) | 0.151 ± 0.028 | 1.977 ± 0.997* | 0.012 ± 0.003## | 0.062, 0.037 | |
| NCLB (µg·hr/mL) | 8.811 ± 0.559 | 29.643 ± 8.979* | 1.347 ± 0.067 | 19.380, 12.721 | |
| NCLB/CLB | 59.5 ± 7.97 | 16.4 ± 3.92*** | 115.9 ± 28.9# | 311.06, 341.04 | |
AUC0–24, AUC from 0 to 24 hours.