AUC ratios of triazolam and its metabolites in WT, 2c3aKO, and hCYP3A/2c3aKO mice Data are expressed as means ± S.D. (n = 4 per group). *P < 0.05; **P < 0.01 compared with WT (one-way ANOVA with a post hoc test of Scheffé’s F test).
| Metabolite/Triazolam | WT | 2c3aKO | hCYP3A/2c3aKO |
|---|---|---|---|
| 1’-Hydroxytriazolam/triazolam | 3.19 ± 0.35 | 0.0137 ± 0.0021** | 0.113 ± 0.032** |
| 4-Hydroxytriazolam/triazolam | 0.600 ± 0.070 | 0.407 ± 0.238 | 0.222 ± 0.064* |