A summary of the historic data used for the retrospective analysis
Dataset is broken down by species, in vitro system, and number of metabolites identified. Columns two through four represent the number of in vitro/in vivo study pairs that have liver microsomes, suspension hepatocytes, and cocultured hepatocytes as their in vitro matrix, respectively. Columns six and seven contain the average number of metabolites identified in the in vivo circulating profiles and the in vitro profiles, respectively.
| Species | Liver microsomes | Suspension Hepatocytes | Cocultured Hepatocytes | Total In Vitro/In Vivo Study Pairs | Average No. of Circulating Metabolitesa | Average No. of In Vitro Metabolitesa |
|---|---|---|---|---|---|---|
| Human | 3 | 15 | 0 | 18 | 3.1 (±2.8) | 3.2 (±3.9) |
| Mouse | 3 | 7 | 0 | 10 | 4.4 (±4.3) | 3.3 (±2.2) |
| Rat | 4 | 81 | 5 | 90 | 2.8 (±2.3) | 4.6 (±4.6) |
| Dog | 4 | 12 | 0 | 16 | 1.9 (±2.0) | 2.5 (±3.2) |
| Monkey | 1 | 3 | 0 | 4 | 5 (±2) | 5 (±6.7) |
| Grand total | 15 | 118 | 5 | 138 | 2.9 (±2.5) | 4.0 (±4.3) |
↵aError in parentheses is S.D.